Does Metabolic Syndrome Influence Surgical Success? Outcomes of Transurethral Resection of Prostate and Open Prostatectomy in Large-Volume Benign Prostate Hyperplasia

UĞURLU M., Aytekin C., Toptas M., BULUT E. C., POLAT F., Yesil S., ...More

LUTS-LOWER URINARY TRACT SYMPTOMS, vol.17, no.5, 2025 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2025
  • Doi Number: 10.1111/luts.70027
  • Journal Name: LUTS-LOWER URINARY TRACT SYMPTOMS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, MEDLINE
  • Gazi University Affiliated: Yes

Abstract

Objective: This study aimed to compare the perioperative outcomes of open prostatectomy (OP) and transurethral resection of the prostate (TURP) in patients with large-volume benign prostatic hyperplasia (BPH) and to evaluate the impact of metabolic syndrome (MetS) on surgical outcomes. Materials and methods: In this retrospective study, 239 patients with a prostate volume greater than 80 cc who underwent TURP (n = 122) or OP (n = 117) between 2018 and 2024 were included. MetS was diagnosed according to NCEP-ATP III 2005 criteria. Postoperative IPSS, Qmax, PVR, hemoglobin levels, and complication rates were compared between groups and by MetS status. Results: Both groups demonstrated significant improvements in IPSS and Qmax postoperatively (p < 0.001). MetS did not significantly impact postoperative IPSS, Qmax, or PVR in either group (p > 0.05). MetS components such as HDL, triglycerides, and waist circumference showed no meaningful correlation with surgical outcomes. Discussion: In patients with large prostate volumes, both surgical techniques yielded significant symptomatic improvement; while metabolic syndrome did not significantly influence postoperative IPSS, Qmax, or PVR outcomes.