Is It Possible to Predict Pulmonary Complications and Mortality in Hematopoietic Stem Cell Transplantation Recipients from Pre-Transplantation Exhaled Nitric Oxide Levels?

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KÖKTÜRK N., Yildirim F., AYDOĞDU M., Aki S. Z., YEGİN Z. A., ÖZKURT Z. N., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.33, sa.1, ss.34-40, 2016 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4274/tjh.2014.0159
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.34-40
  • Anahtar Kelimeler: Hematopoietic stem cell transplantation, Exhaled nitric oxide, Pulmonary complications, Mortality, BONE-MARROW-TRANSPLANTATION, VERSUS-HOST-DISEASE, OBLITERANS ORGANIZING PNEUMONIA, BRONCHIOLITIS OBLITERANS, GRAFT, AGE
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Chemo/radiotherapy-induced free oxygen radicals and reactive oxygen derivatives contribute to the development of early and late transplantation-related pulmonary and extra-pulmonary complications in hematopoietic stem cell transplantation (HSCT) recipients. It has been proposed that an increase in fractional exhaled nitric oxide (FeNO) level indicates oxidative stress and inflammation in the airways. The aim of this prospective study is to evaluate the pre-transplantation FeNO levels in HSCT patients and to search for its role in predicting post-transplantation pulmonary complications and mortality.