Influence of Folate-Related Gene Polymorphisms on High-Dose Methotrexate-Related Toxicity and Prognosis in Turkish Children with Acute Lymphoblastic Leukemia

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Yazıcıoğlu B., Kaya Z., Ergun S. G., Percin F. E., Koçak Ü., Yenicesu I., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.34, no.2, pp.143-150, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.4274/tjh.2016.0007
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.143-150
  • Keywords: Methotrexate, Toxicity, Prognosis, Folate-related gene polymorphisms, THYMIDYLATE SYNTHASE GENE, METHYLENETETRAHYDROFOLATE REDUCTASE C677T, THERAPY, MTHFR, PHARMACOGENETICS, ASSOCIATION, SURVIVAL, PATHWAY, RISK, METAANALYSIS
  • Gazi University Affiliated: Yes

Abstract

Objective: High-dose methotrexate (HD-MTX) is widely used in the consolidation phase of childhood acute lymphoblastic leukemia (ALL), but the roles that polymorphisms in folate-related genes (FRGs) play in HD-MTX toxicity and prognosis in children with ALL are not understood. The aims of this study were to investigate the frequencies of polymorphisms in the genes for thymidylate synthase (TS), methionine synthase reductase (MTRR), and methylene tetrahydrofolate reductase (MTHFR) in Turkish children with ALL and to assess associations between these polymorphisms and HD-MTX-related toxicity and leukemia prognosis in this patient group.