Angiotensin-converting enzyme for noninvasive assessment of liver fibrosis in autoimmune hepatitis

Efe C., Cengiz M., Kahramanoglu-Aksoy E., YILMAZ B., Ozseker B., Beyazit Y., ...Daha Fazla

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, cilt.27, sa.6, ss.649-654, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/meg.0000000000000355
  • Dergi Adı: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.649-654
  • Anahtar Kelimeler: angiotensin-converting enzyme, autoimmune hepatitis, fibrosis, noninvasive markers, renin-angiotensin system, TRANSIENT ELASTOGRAPHY, DISEASE, MULTICENTER, PROGRESSION, DIAGNOSIS, OUTCOMES, VALUES, BIOPSY, SYSTEM
  • Gazi Üniversitesi Adresli: Evet

Özet

Background and aim There are no validated noninvasive markers of liver fibrosis in autoimmune hepatitis (AIH). An activated renin-angiotensin system (RAS) and its key element angiotensin-converting enzyme (ACE) have been implicated in the pathogenesis of hepatic fibrogenesis. We aimed to study the assumed role of activated RAS in the fibrogenic process and whether the serum concentration of ACE can predict different fibrosis stages in AIH.