Telmisartan loaded polycaprolactone/gelatin-based electrospun vascular scaffolds

BİRER M., ACARTÜRK F.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.71, sa.11, ss.858-873, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/00914037.2021.1915785
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.858-873
  • Anahtar Kelimeler: Electrospinning, gelatin, telmisartan, tissue engineering, vascular scaffold, ENDOTHELIAL-CELLS, NITRIC-OXIDE, IN-VITRO, NANOFIBROUS SCAFFOLDS, GELATIN NANOFIBER, GRAFTS, HEPARIN, FABRICATION, RELEASE, SYSTEM
  • Gazi Üniversitesi Adresli: Evet

Özet

Small diameter vascular grafts are frequently used in the treatment of cardiovascular diseases. The aim of this study is to design electrospun telmisartan (TEL)-loaded polycaprolactone/gelatin (GEL) based vascular scaffold prototypes. A series of drug-free and TEL-loaded scaffolds were electrospun. When best formulations considered, mean fiber diameters were found as 1,133 and 1,120 nm, contact angles were found as 0 degrees and 110 degrees for drug-free and TEL loaded formulation, respectively. Biaxial tensile strength, elongation at break, and Young modulus analyses were also performed. The results of the study proved that the scaffolds were found to be promising material for using human blood vessels.