Akademik Veri Yönetim Sistemi
TURKISH JOURNAL OF ORTHODONTICS, cilt.23, sa.3, ss.212-225, 2010 (ESCI)
Aim: The aim of this experimental study was to evaluate the advancement of premaxilla with a bone-tooth borne distractors using the landmarks on standard lateral cephalograms and the effects of TGF beta 1 on bone healing. Materials and Methods: Fourteen rabbits were divided in 3 groups where first group (n=7) was treated with distraction osteogenesis, second group (n=5) was treated with distraction osteogenesis combined with external TGF beta 1 application, and 2 rabbits were treated only with corticotomy as controls. Following anesthesia and adaptation of the individual distractors, corticotomy of palatal bone and lateral maxillary walls for distraction was made. The distraction has started 3 days following the surgical procedure, and the device was activated 0.6 mm each day for 8 days. External TGFI beta application was made following 24 hours of the initial expansion in animals where distraction was combined with the application of growth factor. Animals were sacrificed after 12 days of retention period and specimens were collected for histological examination. Results: The amount of anterior movement of the premaxilla was found 3.79 mm for the distraction osteogenesis group and 3.7 mm for the group where external TGF beta application was made following distraction. ConcCleft palate, alveolar distraction, secondary alveolar bone grafting.ups, histological bone healing was much better in TGEgl treated group.