Reanastomoses of freshly divided right uterine horns of rats were performed by fibrin sealant in 10 animals (group 1) and by conventional microsurgery in 10 animals (group 2). No surgical procedure was performed on the left horns, which were used as controls. The tubal patency rate in group 1 was found to be lower than that of group 2 (60% vs 90%). The mean adhesion scores of groups 1 and 2 and control were 1.7, 1.4, and 0.4, respectively. The mean scores of mucosal regeneration in groups 1 and 2 were 2.0 and 1.8, and the mean scores of disruption of the muscularis layer were 1.7 and 1.6, respectively. Although the scores of adhesion formation and histologic grading in group 1 were higher than those in group 2, the differences were not significant. The ultrastructural examination (Light and scanning electron microscope) of the reanastomosis sites of group 1 was comparable with that of group 2. We conclude that although fibrin sealant seems to be an alternative to microsurgery, with comparable results, it is premature to use fibrin glue in the human being in the light of this animal study.