4-(5-chloro-2(3H)-benzoxazolon-3-yl) butanoic acid derivatives: Synthesis, antinociceptive and anti-inflammatory properties

Gulcan H., Kupeli E., Unlu S., Yesilada E., Sahin M.

ARCHIV DER PHARMAZIE, vol.336, no.10, pp.477-482, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 336 Issue: 10
  • Publication Date: 2003
  • Doi Number: 10.1002/ardp.200300722
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.477-482
  • Keywords: 2(3H)-benzoxazolone, butanamides, synthesis, antinociceptive, anti-inflammatory, 6-ACYL BENZOXAZOLINONES
  • Gazi University Affiliated: No


In this study, 4-(5-chloro-2(3H)-benzoxazolone-3-yl)butanoic acid and its ethyl ester as well as its ten new amide derivatives have been synthesized. Their structures have been elucidated by IR, H-1-NMR spectra and elemental analysis. The compounds were screened for antinociceptive and anti-inflammatory activities. The highest antinociceptive and anti-inflammatory activities were exhibited by Compound 11 which has carboxylic acid structure. A various decrease in antinociceptive and anti-inflammatory activity was observed by amidation of the carboxylic acid moiety of this compound.