4-(5-chloro-2(3H)-benzoxazolon-3-yl) butanoic acid derivatives: Synthesis, antinociceptive and anti-inflammatory properties
ARCHIV DER PHARMAZIE, cilt.336, sa.10, ss.477-482, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 336 Sayı: 10
- Basım Tarihi: 2003
- Doi Numarası: 10.1002/ardp.200300722
- Dergi Adı: ARCHIV DER PHARMAZIE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.477-482
- Anahtar Kelimeler: 2(3H)-benzoxazolone, butanamides, synthesis, antinociceptive, anti-inflammatory, 6-ACYL BENZOXAZOLINONES
- Gazi Üniversitesi Adresli: Evet
Özet
In this study, 4-(5-chloro-2(3H)-benzoxazolone-3-yl)butanoic acid and its ethyl ester as well as its ten new amide derivatives have been synthesized. Their structures have been elucidated by IR, H-1-NMR spectra and elemental analysis. The compounds were screened for antinociceptive and anti-inflammatory activities. The highest antinociceptive and anti-inflammatory activities were exhibited by Compound 11 which has carboxylic acid structure. A various decrease in antinociceptive and anti-inflammatory activity was observed by amidation of the carboxylic acid moiety of this compound.