4-(5-chloro-2(3H)-benzoxazolon-3-yl) butanoic acid derivatives: Synthesis, antinociceptive and anti-inflammatory properties

Gulcan H., Kupeli E., Unlu S., Yesilada E., Sahin M.

ARCHIV DER PHARMAZIE, cilt.336, sa.10, ss.477-482, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 336 Konu: 10
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1002/ardp.200300722
  • Sayfa Sayıları: ss.477-482


In this study, 4-(5-chloro-2(3H)-benzoxazolone-3-yl)butanoic acid and its ethyl ester as well as its ten new amide derivatives have been synthesized. Their structures have been elucidated by IR, H-1-NMR spectra and elemental analysis. The compounds were screened for antinociceptive and anti-inflammatory activities. The highest antinociceptive and anti-inflammatory activities were exhibited by Compound 11 which has carboxylic acid structure. A various decrease in antinociceptive and anti-inflammatory activity was observed by amidation of the carboxylic acid moiety of this compound.