Synthesis of Some Novel Thiocyanotopurine Derivatives and Investigation of Their Antimicrobial Activity and DNA Interactions

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Celik G. D. , DİŞLİ A. , Oner Y., AÇIK L.

CHEMICAL & PHARMACEUTICAL BULLETIN, cilt.60, sa.5, ss.578-582, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Konu: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1248/cpb.60.578
  • Sayfa Sayıları: ss.578-582


A series of 6-thiocyanatopurine derivatives introduced with different alkyl groups in position 9 was synthesized. The structures of the synthesized compounds were evaluated via spectroscopic methods and elemental methods of analyses. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against yeast strains. All the synthesized compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. DNA interactions with pBR322 DNA were determined. Most of the compounds caused conformational changes in DNA.