Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity

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Aytemir M., Özçelik B., Karakaya G.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.23, sa.12, ss.3646-3649, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 12
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.bmcl.2013.03.098
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3646-3649
  • Anahtar Kelimeler: Synthesis, Chlorokojic acid, Mannich base, Cytotoxicity, Antidermatophytic activity, ANTIMICROBIAL ACTIVITIES, ANTICONVULSANT, DESIGN
  • Gazi Üniversitesi Adresli: Evet

Özet

In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum. (C) 2013 Elsevier Ltd. All rights reserved.