Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity


AYTEMİR M., ÖZÇELİK B. , Karakaya G.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.23, sa.12, ss.3646-3649, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 23 Konu: 12
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.bmcl.2013.03.098
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Sayfa Sayıları: ss.3646-3649

Özet

In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum. (C) 2013 Elsevier Ltd. All rights reserved.