Akademik Veri Yönetim Sistemi
XXXIII. WASPaLM World Congress & XXIV. National Clinicial Biochemistry Congress , Antalya, Türkiye, 16 - 20 Ekim 2024, ss.110
Aim: Bisalbuminemia or alloalbuminemia is an inherited or acquired, rarely encountered serum protein anomaly, characterized by the occurrence of bicuspid electrophoretic pattern in the albumin fraction detected on serum protein electrophoresis. These albumin mutants also called alloalbumins either have increased electrophoretic mobility (fast type variants) or decreased mobility (slow type variants). We aimed to investigate and present the bisalbuminemic pattern in the serum protein electrophoresis of the patient with chronic pancreatitis. Methods: The case is a 52-year-old male patient with chronic pancreatitis under follow-up. The patient's serum protein electrophoresis was performed using the capillary electrophoresis method. Results: A 52-year-old male with multiple comorbidities, who has had chronic pancreatitis attacks related to hypertriglyceridemia and alcohol for 17 years, presented to the hospital with complaints of weight loss and B symptoms. The patient also had anemia and elevated sedimentation rate. A bisalbuminemic pattern was observed in the serum protein analysis conducted for further investigation. The patient underwent a thoracoabdominal Computed Tomography scan, which revealed a 5 cm collection in the splenic area. According to the biochemical analysis of the material obtained from the collection in the splenic locus, the results were as follows: Amylase >1500 U/L, Lipase 15225 U/L. According to the Endoscopic Retrograde Cholangiopancreatography report, a pancreatic duct-associated cyst was observed. The patient underwent abscess drainage and a drain was placed in the abscess area. The patient was initiated on antibiotic treatment based on the recommendation of infectious disease specialists. A stent was placed distally to the pancreatic duct during the Endoscopic Retrograde Cholangiopancreatography procedure performed on the patient. After treatment, a bipcuspid electrophoretic pattern was not observed in the albumin band. Conclusion : The presence of a bifid peak in the protein electrophoresis conducted during the initial admission of the patient, who presented with a pancreatitis attack, and its disappearance after treatment, suggest that bisalbuminemia is due to pancreatitis. Human pancreatic juice can produce fast and slow-type albumins by proteolytic enzymes, and they are seen in patients with pancreatic ascites. Keywords: bisalbuminemia, bifid peak, serum protein electrophoresis, albumin band, chronic pancreatitis, amylase, lipase, pancreatic duct-associated cyst