Akademik Veri Yönetim Sistemi
JOURNAL OF MOLECULAR HISTOLOGY, cilt.57, sa.1, 2026 (SCI-Expanded, Scopus)
Fenamiphos (FNP) is an organophosphate compound used to control many agricultural pests. Naringenin (NAR) is a compound that has been recognized as a having physiologically potent antioxidant activity. This study was made to detect the possible therapeutic effects of NAR in preventing fenamiphos-induced reproductive toxicity. For this purpose, rats were treated with Fenamiphos (FNP) and Naringenin (NAR) for 4 weeks. This study was conducted on a total of 24 adult male albino rats. The rats were divided in an equally random manner into four groups: Group 1 was determined as the control group; group II received a dose of 50 mg/kg naringenin orally; group III received fenamiphos in a dose of 0.76 mg/kg/day orally; group IV received both naringenin and fenamiphos in the same stated doses. The results obtained in the testis showed a significant increase in the malondialdehyde, 8-OHdG, IL-17, and a significant decrease in superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, acetylcholine esterase activities, testosterone, FSH, and LH contents in the FNP-treated group. Tissue damage induced significant histopathological/immunohistochemical changes following exposure to FNP. Treatment with NAR reduced malondialdehyde, 8-OHdG, and IL-17 contents, and naringenin treatment caused an increase in superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, acetylcholine esterase, testosterone, FSH, and LH parameters compared with the FNP-treated groups. Micrographs of testis sections in FNP plus NAR-treated rats showed fewer histopathological and immunohistochemical changes. Flavonoids could effectively protect against fenamiphos-induced damage, offering a potential solution for pesticide-related toxicity. In this investigation, it was shown that fenamiphos caused testicular toxicity, and naringenin reduced this toxicity.