EFFECT OF SHORT-TERM alpha-TOCOPHEROL SUPPLEMENTATION ON BIOMARKERS OF OXIDATIVE STRESS AND ANTIOXIDANT DEFENCE IN SUBJECTS WITH ANGINA PECTORIS


Hacisevki A., Torun M., Cengel A.

OXIDATION COMMUNICATIONS, vol.35, no.1, pp.128-137, 2012 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2012
  • Title of Journal : OXIDATION COMMUNICATIONS
  • Page Numbers: pp.128-137

Abstract

The aim of placebo-controlled double-blind study was to investigate the levels of oxidant and antioxidant biomarkers and lipids and to evaluate the effect of short-term alpha-tocopherol supplementation (400 IU/day) on these parameters. In the groups who received alpha-tocopherol there was a significant increase in serum alpha-tocopherol concentrations (p<0.05). Plasma malondialdehyde levels of patient groups were significantly higher than those of control groups both before and after treatment. Plasma malondialdehyde levels decreased significantly after treatment. There was no statistical difference between case and control groups in terms of lipids. Cholesterol and LDL-cholesterol levels decreased after treatment. While vitamins E and C concentrations in serum were lower in the patient group than the controls, there was no difference for beta-carotene. They were found to be higher in the treatment group than in the patient group except vitamin C.