Lycopene prevents experimental priapism against oxidative and nitrosative damage


ÇİFTÇİ O., Oguz F., Beytur A., Polat F., Altintas R., Oguzturk H.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.18, no.21, pp.3320-3325, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 21
  • Publication Date: 2014
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3320-3325
  • Keywords: Priapism, Lycopene, Oxidative stress, Nitrosative stress, Cavernosal tissue, NITRIC-OXIDE PRODUCTION, CHEMOTHERAPY, CANCER, ASSAY
  • Gazi University Affiliated: Yes

Abstract

OBJECTIVE: Priapism is a persistent and often painful penile erection in the absence of sexual stimulation. It can cause progressive fibrosis, edema and drying of the erectile tissue and then it can lead to erectile dysfunction. Previous studies suggested that, neuronal nitric oxide levels increased during the priapism. High NO levels can result in the formation of reactive oxygen species (ROS) leading to oxidative stress in tissue and reproductive system. The aim of this study was to evaluate oxidative and nitrosative effects caused by priapism in cavernosal tissue and serum, and determinate beneficial effects of lycopene on ischemic priapism.