Protein bio-corona: critical issue in immune nanotoxicology


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Neagu M., Piperigkou Z., Karamanou K., ENGİN A. B., Docea A. O., Constantin C., ...More

ARCHIVES OF TOXICOLOGY, vol.91, no.3, pp.1031-1048, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 91 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1007/s00204-016-1797-5
  • Journal Name: ARCHIVES OF TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1031-1048
  • Keywords: Bio-corona, Nanoparticle, Immunological identity, WALLED CARBON NANOTUBES, PEG CHAIN-LENGTH, COMPLEMENT ACTIVATION, NANOPARTICLE SIZE, PLASMA-PROTEINS, FUNCTIONAL-PROPERTIES, GOLD NANOPARTICLES, PARTICLE-SIZE, GLOBULAR-HEAD, ADSORPTION
  • Gazi University Affiliated: Yes

Abstract

With the expansion of the nanomedicine field, the knowledge focusing on the behavior of nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex biological system, nanomaterials dynamically interact with all the encountered biomolecules and form the protein "bio-corona." The decoration with these surface biomolecules endows nanoparticles with new properties. The present review will address updates of the protein bio-corona characteristics as influenced by nanoparticle's physicochemical properties and by the particularities of the encountered biological milieu. Undeniably, bio-corona generation influences the efficacy of the nanodrug and guides the actions of innate and adaptive immunity. Exploiting the dynamic process of protein bio-corona development in combination with the new engineered horizons of drugs linked to nanoparticles could lead to innovative functional nanotherapies. Therefore, bio-medical nanotechnologies should focus on the interactions of nanoparticles with the immune system for both safety and efficacy reasons.