Protein bio-corona: critical issue in immune nanotoxicology

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Neagu M., Piperigkou Z., Karamanou K., ENGİN A. B. , Docea A. O. , Constantin C., ...Daha Fazla

ARCHIVES OF TOXICOLOGY, cilt.91, sa.3, ss.1031-1048, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 91 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s00204-016-1797-5
  • Sayfa Sayıları: ss.1031-1048


With the expansion of the nanomedicine field, the knowledge focusing on the behavior of nanoparticles in the biological milieu has rapidly escalated. Upon introduction to a complex biological system, nanomaterials dynamically interact with all the encountered biomolecules and form the protein "bio-corona." The decoration with these surface biomolecules endows nanoparticles with new properties. The present review will address updates of the protein bio-corona characteristics as influenced by nanoparticle's physicochemical properties and by the particularities of the encountered biological milieu. Undeniably, bio-corona generation influences the efficacy of the nanodrug and guides the actions of innate and adaptive immunity. Exploiting the dynamic process of protein bio-corona development in combination with the new engineered horizons of drugs linked to nanoparticles could lead to innovative functional nanotherapies. Therefore, bio-medical nanotechnologies should focus on the interactions of nanoparticles with the immune system for both safety and efficacy reasons.