Relationship between SIRT1 gene expression level and disease in age-related cataract cases

Agaoglu N. B., Varol N., Yildiz S. H., Karaosmanoglu C., Duman R., Erdogan M. O., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.49, sa.4, ss.1068-1072, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3906/sag-1810-182
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1068-1072
  • Anahtar Kelimeler: Age-related cataract, epigenetics mechanisms, SIRT1, RISK-FACTORS
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: Age-related cataract is the most important visual impairment all over the world. Epigenetic modifications, especially overexpression of histone deacetylases, have become the focus of interest for cataract development in recent years. Sirtuin 1 (SIRT1), a class II histone deacetylase and a member of the sirtuin family, is one of the best-characterized histone deacetylases and has a pivotal role in age-related diseases. However, the association of SIRT1 with age-related cataracts has not yet been fully elucidated. Therefore, we aimed to determine the expression of SIRT1 in age-related cataract patients.