The effect of taurine on polymorphonuclear leukocyte functions in endotoxemia

Erdamar H., Tuerkoezkan N., Ekremoglu M., Kurt Y., Yaman H.

AMINO ACIDS, cilt.33, sa.4, ss.581-585, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Konu: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00726-007-0543-y
  • Dergi Adı: AMINO ACIDS
  • Sayfa Sayıları: ss.581-585


The aim of the present study was to measure MPO activity in PMN leukocytes after endotoxin administration, and to compare the levels of NO2- competing with taurine for reaction with HOCl. Furthermore we aimed to determine TauCl levels, a product of MPO-H2O2-Halide system, and to evaluate anti-inflammatory properties of PMN in endotoxemia. In addition, our second objective was to investigate the effect of taurine, an antioxidant amino acid, on anti-bactericidal and anti-inflammatory functions of PMN after administration of endotoxin together with taurine.