Preparation and evaluation of a prolonged release pentoxifylline tablet with chitosan


Inoyatov N., Celebi N., Acarturk F.

PHARMAZEUTISCHE INDUSTRIE, vol.60, no.5, pp.472-475, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 5
  • Publication Date: 1998
  • Journal Name: PHARMAZEUTISCHE INDUSTRIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.472-475
  • Keywords: chitosan, pentoxifylline tablets, prolonged release tablets, DIRECTLY COMPRESSED TABLETS, PHARMACEUTICAL INTERACTIONS, DOSAGE FORMS, SUSTAINED-RELEASE, CHITIN, PHARMACOKINETICS
  • Gazi University Affiliated: Yes

Abstract

This study was an attempt to prepare a prolonged release pentoxifylline tablet with chitosan. Effects of chitosan on the release profile of pentoxifylline were studied using USP XXII paddle method. Dissolution studies were carried out at pH 1.2 followed by pH 4.0 and finally by pH 7.0 for 1.5, 2.5 and 4 h, respectively.