Reduction in camera-specific variability in [I-123]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

Buchert, Ralph; Kluge, Andreas; Tossici-Bolt, Livia; Dickson, John; Bronzel, Marcus; Lange, Catharina; Asenbaum, Susanne; Booij, Jan; Kapucu, LÜTFİYE; Svarer, Claus; Koulibaly, Pierre-Malick; Nobili, Flavio; Pagani, Marco; Sabri, Osama; Sera, Terez; Tatsch, Klaus; Vander Borght, Thierry; Van Laere, Koen; Varrone, Andrea; Iida, Hidehiro

doi:10.1007/s00259-016-3309-5

Reduction in camera-specific variability in [I-123]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls

Buchert R., Kluge A., Tossici-Bolt L., Dickson J., Bronzel M., Lange C., ...Daha Fazla

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, cilt.43, sa.7, ss.1323-1336, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 43 Sayı: 7
Basım Tarihi: 2016
Doi Numarası: 10.1007/s00259-016-3309-5
Dergi Adı: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1323-1336
Anahtar Kelimeler: QSPECT, Dopamine transporter scintigraphy, [I-123]FP-CIT, Specific binding ratio, Age, ENC-DAT, CEREBRAL-BLOOD-FLOW, SPLIT-DOSE I-123-IODOAMPHETAMINE, DOPAMINE TRANSPORTER SPECT, FP-CIT SPECT, PARKINSONS-DISEASE, SCATTER CORRECTION, LEWY BODIES, SEMIQUANTITATIVE ANALYSIS, QUANTITATIVE ASSESSMENT, I-123-FP-CIT SPECT
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Gazi Üniversitesi Adresli: Evet

Özet

Purpose Quantitative estimates of dopamine transporter availability, determined with [I-123]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [I-123]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis.