Reduction in camera-specific variability in [I-123]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls


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Buchert R., Kluge A., Tossici-Bolt L., Dickson J., Bronzel M., Lange C., ...More

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol.43, no.7, pp.1323-1336, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 7
  • Publication Date: 2016
  • Doi Number: 10.1007/s00259-016-3309-5
  • Journal Name: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1323-1336
  • Keywords: QSPECT, Dopamine transporter scintigraphy, [I-123]FP-CIT, Specific binding ratio, Age, ENC-DAT, CEREBRAL-BLOOD-FLOW, SPLIT-DOSE I-123-IODOAMPHETAMINE, DOPAMINE TRANSPORTER SPECT, FP-CIT SPECT, PARKINSONS-DISEASE, SCATTER CORRECTION, LEWY BODIES, SEMIQUANTITATIVE ANALYSIS, QUANTITATIVE ASSESSMENT, I-123-FP-CIT SPECT
  • Gazi University Affiliated: Yes

Abstract

Purpose Quantitative estimates of dopamine transporter availability, determined with [I-123]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [I-123]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis.