Electrochemical Biosensor Design with Multi-walled Carbon Nanotube to Display DNA-Schiff Base Interaction

Munir A., Bozal-Palabiyik B., EREN G., Shah A., Ali S., Uddin N., ...More

ELECTROANALYSIS, vol.33, pp.1761-1770, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 33
  • Publication Date: 2021
  • Doi Number: 10.1002/elan.202100156
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1761-1770
  • Keywords: Schiff base, DNA biosensor, carbon nanotube, voltammetry, molecular docking
  • Gazi University Affiliated: Yes


This paper demonstrates a Schiff base i. e. 5-(diethylamino)-2-((2,6-diethylphenylimino)methyl)phenol (5-DDMP) that was sensed by DNA biosensor. dsDNA was immobilized onto GCE modified with functionalized multi-walled carbon nanotubes to prepare a biosensor. The efficiency of dsDNA biosensor was determined and binding of 5-DDMP with dsDNA was searched by UV-vis spectrophotometry and differential pulse voltammetry. Molecular docking simulations between 5-DDMP and dsDNA were explored and as a result, a hydrogen bond and a pi-pi contact were observed between 5-DDMP and deoxyguanosine base (dG22) of the strand B, deoxyadenosine base (dA5) of the strand A, respectively. These studies could be useful for new anticancer drug design and development.