Evaluation of clinical characteristics, diagnosis and management in childhood immune thrombocytopenic purpura: a single center's experience.

Kocak U., Aral Y. Z., Kaya Z., Oeztuerk G., Guersel T.

The Turkish journal of pediatrics, cilt.49, sa.3, ss.250-5, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: The Turkish journal of pediatrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.250-5
  • Anahtar Kelimeler: children, immune thrombocytopenic purpura, treatment, INTRAVENOUS IMMUNOGLOBULIN, INTRACRANIAL HEMORRHAGE, RANDOMIZED TRIAL, RETROSPECTIVE ANALYSIS, AMERICAN-SOCIETY, CHILDREN, METHYLPREDNISOLONE, THERAPY, GUIDELINES, GLOBULIN
  • Gazi Üniversitesi Adresli: Evet

Özet

purpura (ITP) are controversial. We reviewed the files of 162 children with ITP to evaluate clinical characteristics, response to treatment and outcome. History of antecedent infection, vaccination and serologic evidence for acute viral infection were present in 48%, 5% and 17% of the patients, respectively. At diagnosis, two-thirds of the patients had a platelet count of < 10,000/mu 1 but only 10% had major bleedings. Intracranial hemorrhage was seen in two patients (1.2%) with a mortality rate of 0.6%. Sixteen percent developed chronic ITP. The rate of platelet recovery with mega-dose methylprednisolone (30 mg/kg/d for 3 and 20 mg/kg/d for 4 days) was similar to that obtained with intravenous immunoglobulin or oral prednisolone. Four of seven patients with ITP responded to splenectomy. These data show that mode of treatment has no effect on the clinical course and prognosis of childhood ITP.