Relationship of Ki67, TP53, MDM-2 and BCL-2 expressions with WHO 1973 and WHO/ISUP grades, tumor category and overall patient survival in urothelial tumors of the bladder.

IŞIK GÖNÜL İ., Akyuerek N., DURSUN A., Kuepeli B.

Pathology, research and practice, cilt.204, sa.10, ss.707-17, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 204 Sayı: 10
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.prp.2008.03.011
  • Dergi Adı: Pathology, research and practice
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.707-17
  • Anahtar Kelimeler: Urothelial carcinoma, Grading, Oncogenes, Proliferative activity, TRANSITIONAL-CELL CARCINOMA, GROWTH-FACTOR RECEPTOR, C-ERB B-2, URINARY-BLADDER, PROGNOSTIC VALUE, IMMUNOHISTOCHEMICAL EXPRESSION, PATHOLOGY CLASSIFICATION, CLINICAL-SIGNIFICANCE, P53 EXPRESSION, MITOTIC INDEX
  • Gazi Üniversitesi Adresli: Evet

Özet

Using the 1998 World Health Organization/International Society of Urological Pathology (WHO/ISUP) (2004 WHO), 1999 WHO/ISUP, and 1973 WHO classifications, we examined Ki67, BCL-2, TP53, and MDM-2 expressions in invasive and noninvasive urothelial neoplasias of the bladder of 72 patients, and compared the results regarding tumor category and grade with clinical outcome to determine the clinicopathological relevance of these classifications.