Relationship of Ki67, TP53, MDM-2 and BCL-2 expressions with WHO 1973 and WHO/ISUP grades, tumor category and overall patient survival in urothelial tumors of the bladder.

IŞIK GÖNÜL İ., Akyuerek N., DURSUN A., Kuepeli B.

Pathology, research and practice, vol.204, no.10, pp.707-17, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 204 Issue: 10
  • Publication Date: 2008
  • Doi Number: 10.1016/j.prp.2008.03.011
  • Journal Name: Pathology, research and practice
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.707-17
  • Keywords: Urothelial carcinoma, Grading, Oncogenes, Proliferative activity, TRANSITIONAL-CELL CARCINOMA, GROWTH-FACTOR RECEPTOR, C-ERB B-2, URINARY-BLADDER, PROGNOSTIC VALUE, IMMUNOHISTOCHEMICAL EXPRESSION, PATHOLOGY CLASSIFICATION, CLINICAL-SIGNIFICANCE, P53 EXPRESSION, MITOTIC INDEX
  • Gazi University Affiliated: Yes

Abstract

Using the 1998 World Health Organization/International Society of Urological Pathology (WHO/ISUP) (2004 WHO), 1999 WHO/ISUP, and 1973 WHO classifications, we examined Ki67, BCL-2, TP53, and MDM-2 expressions in invasive and noninvasive urothelial neoplasias of the bladder of 72 patients, and compared the results regarding tumor category and grade with clinical outcome to determine the clinicopathological relevance of these classifications.