Granulomatous interstitial nephritis associated with Primary Sjogren's syndrome

Bitik B., Gonul I. I., Haznedaroglu S., Goker B., TUFAN A.

ZEITSCHRIFT FUR RHEUMATOLOGIE, cilt.76, sa.5, ss.458-460, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s00393-017-0269-5
  • Dergi Adı: ZEITSCHRIFT FUR RHEUMATOLOGIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.458-460
  • Anahtar Kelimeler: Sjogren's syndrome, Granulomatous interstitial nephritis, Rituximab, Sarcoidosis, TUBULOINTERSTITIAL NEPHRITIS, RENAL SARCOIDOSIS, INVOLVEMENT, CRITERIA, DISEASE
  • Gazi Üniversitesi Adresli: Evet

Özet

Primary Sjogren's syndrome (pSS) is an autoimmune disease characterized by lymphocytic and plasmacytic infiltration of the exocrine glands. Tubulointerstitial nephritis (TIN) is the most common type of renal involvement in pSS. However, clinically significant renal involvement is uncommon. Granulomatous interstitial nephritis (GIN) is a rare histopathological entity characterized by the presence of granulomas against a background of interstitial inflammation. GIN is not a typical and commonly seen form of TIN in pSS. Herein, we report on a patient who was concurrently diagnosed with pSS and GIN and was treated successfully with rituximab (RTX). pSS should be considered in the differential diagnosis of GIN, and RTX may be a good option in the treatment of this patient group.