Corneal aldehyde dehydrogenase and glutathione S-transferase activity after excimer laser keratectomy in guinea pigs


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Bilgihan K., Bilgihan A., Hasanreisoglu B., Turkozkan N.

BRITISH JOURNAL OF OPHTHALMOLOGY, cilt.82, sa.3, ss.300-302, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 82 Konu: 3
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1136/bjo.82.3.300
  • Dergi Adı: BRITISH JOURNAL OF OPHTHALMOLOGY
  • Sayfa Sayıları: ss.300-302

Özet

Background-The free radical balance of the eye may be changed by excimer laser keratectomy. Previous studies have demonstrated that excimer laser keratectomy increases the corneal temperature, decreases the superoxide dismutase activity of the aqueous, and induces lipid peroxidation in the superficial corneal stroma. Aldehyde dehydrogenase (ALDH) and glutathione S-transferase (GST) are known to play an important role in corneal metabolism, particularly in detoxification of aldehydes, which are generated from free radical reactions.