Preparation and swelling properties of temperature-sensitive semi-interpenetrating polymer networks composed of poly[(N-tert-butylacrylamide)-co-acrylamide] and hydroxypropyl cellulose


Caykara T., Sengul G., Birlik G.

MACROMOLECULAR MATERIALS AND ENGINEERING, vol.291, no.9, pp.1044-1051, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 291 Issue: 9
  • Publication Date: 2006
  • Doi Number: 10.1002/mame.200600063
  • Journal Name: MACROMOLECULAR MATERIALS AND ENGINEERING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1044-1051
  • Keywords: crosslinker, hydrogels, interpenetrating polymer network, swelling ratio, POLY(VINYL ALCOHOL), PHASE-TRANSITION, DRUG-DELIVERY, HYDROGELS, RELEASE, CHITOSAN
  • Gazi University Affiliated: No

Abstract

Temperature-responsive hydrogels based on linear HPC and crosslinked P(NTBA-co-AAm) were prepared by the semi-IPN technique. The structure of these semi-IPN hydrogels was investigated by FT-IR spectroscopy. An increase in normalized band ratios (A(2980)/A(1665)) was observed with increasing HPC content in the initial mixture. The swelling kinetics and water transport mechanism of these semi-IPN hydrogels were examined and their temperature responsive behaviors were also investigated by measuring equilibrium swelling ratios and pulsatile swelling experiments. The results showed that these semi-IPN hydrogels underwent a volume phase transition between 18 and 22 degrees C irrespective of the amounts of MBAAm and HPC. However, below the volume phase transition temperature, their equilibrium swelling ratios were affected by the amount of MBAAm and HPC. The pulsatile swelling experiments indicated that the lower the MBAAm and the higher HPC contents in semi-IPN hydrogels the faster the response rate temperature change.