Unexpected Late Response to Ofatumumab in Adult Post-Transplantation Recurrent Focal Segmental Glomerulosclerosis, Case Report


URAL Z., HELVACI Ö., Ozbas B., GÜZ G., DERİCİ Ü.

TRANSPLANTATION PROCEEDINGS, vol.54, no.6, pp.1632-1635, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.1016/j.transproceed.2022.04.019
  • Journal Name: TRANSPLANTATION PROCEEDINGS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1632-1635
  • Gazi University Affiliated: Yes

Abstract

Background. Idiopathic focal segmental glomerulosclerosis is an important cause of kidney failure in adults, which is associated with a high risk of disease recurrence after transplantation. Plasmapheresis, rituximab, immunoadsorption, and high-dose cyclosporine are used to treat post-transplant recurrent focal segmental glomerulosclerosis (rFSGS). However, the response rate is variable, and few options remain for unresponsive patients.Case Report. We present a 44-year-old man with an early post-transplant rFSGS. After peri-transplant plasmapheresis, rituximab, and abatacept treatments failed, we employed ofatumu-mab. After 9 months without apparent benefit, we observed an unexpected partial remission thereafter, without severe side effects. Furthermore, remission has been sustained in 30-month follow-up. Conclusions. We believe ofatumumab can be considered an alternative for patients with plas-mapheresis and rituximab-resistant post-transplant rFSGS.