Adenosine deaminase and guanosine deaminase activities in sera of patients with viral hepatitis

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Kalkan A., Bulut V., EREL Ö., Avci S., Bingol N.

MEMORIAS DO INSTITUTO OSWALDO CRUZ, vol.94, no.3, pp.383-386, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 94 Issue: 3
  • Publication Date: 1999
  • Doi Number: 10.1590/s0074-02761999000300018
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.383-386
  • Keywords: adenosine deaminase, guanosine deaminase, viral hepatitis, TYPHOID-FEVER, VIRUS, REPLICATION, ISOENZYMES, CELLS
  • Gazi University Affiliated: No


In order to investigate purin and primidin metabolism pathways in hepatitis, adenosine deaminase (ADA) and guanosine deaminase (GDA) activities in sera of patients with different types and manifestations of viral hepatitis disease (A, B, C, D, E, chronic, acute) were investigated and compared with the control group of healthy individuals. Hepatitis cases were classified with respect to their serological findings and clinics. When compared all the hepatitis cases with the controls, levels of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase enzymes, as well as ADA and GDA, were significantly higher than rite control group (p<0.01). Levels of ADA and GDA in hepatitis cases were determined as 26.07+/-11.98 IU/l and 2.37+/-1.91 IU/l, respectively.