The inverse association between ANGPTL8 and PI3K-mTOR-PPAR gamma expressions in adipose tissue of high-fructose-fed rats: The modulatory effect of kefir

AKAR F., Guney C., ÖZER H. B., Pektas M. B., Koca H. B., KOCABAŞ A., ...More

ISTANBUL JOURNAL OF PHARMACY, vol.51, no.3, pp.299-306, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2021.933139
  • Journal Name: ISTANBUL JOURNAL OF PHARMACY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.299-306
  • Keywords: Dietary fructose, Kefir, ANGPTL8, PI3K-mTOR-PPAR gamma pathway, Lipogenesis, CAUSES INSULIN-RESISTANCE, PHOSPHATIDYLINOSITOL 3-KINASE, SIGNALING PATHWAY, LIVER, ADIPOCYTES, PROTEIN, FAT, STIMULATION, BETATROPHIN, LIPOGENESIS
  • Gazi University Affiliated: Yes

Abstract

Background and Aims: The dietary high-fructose intake might be a risk factor for several metabolic diseases. Kefir, a fermented milk product, has been proposed to have beneficial health effects. In this study, we aimed to investigate the effects of fructose consumption and kefir supplementation on the lipogenesis-related genes including angiopoietin-like protein 8 (angptl8), phosphoinositide 3-kinase (pi3k), mammalian target of rapamycin (mtor), and peroxisome proliferator-activated receptor gamma (ppar gamma) as well as inflammatory factors in the adipose tissue to provide new mechanistic insights into lipogenesis.