Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy

Kilic D., Egehan I., Ozenirler S., Dursun A.

RADIOTHERAPY AND ONCOLOGY, cilt.57, sa.2, ss.125-129, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 2
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s0167-8140(00)00254-1
  • Dergi Adı: RADIOTHERAPY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.125-129
  • Anahtar Kelimeler: pelvic irradiation, acute radiation enteritis, sulphasalazine, RADIATION-THERAPY, SULFASALAZINE, OLSALAZINE
  • Gazi Üniversitesi Adresli: Hayır

Özet

Background and purpose: Acute radiation-induced diarrhea occurs in approximately 80% of the patients receiving pelvic radiotherapy. It is caused by gastrointestinal irritation and inflammation. Eicosanoids are thought to be one of the mechanisms of this. Sulphasalazine is an inhibitor of their synthesis in the mucosa. This randomized clinical trial was undertaken to evaluate its effect in preventing acute radiation enteritis (ARE).