Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of sulphasalazine in preventing acute gastrointestinal complications due to radiotherapy


Kilic D., Egehan I., Ozenirler S., Dursun A.

RADIOTHERAPY AND ONCOLOGY, vol.57, no.2, pp.125-129, 2000 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 2
  • Publication Date: 2000
  • Doi Number: 10.1016/s0167-8140(00)00254-1
  • Title of Journal : RADIOTHERAPY AND ONCOLOGY
  • Page Numbers: pp.125-129

Abstract

Background and purpose: Acute radiation-induced diarrhea occurs in approximately 80% of the patients receiving pelvic radiotherapy. It is caused by gastrointestinal irritation and inflammation. Eicosanoids are thought to be one of the mechanisms of this. Sulphasalazine is an inhibitor of their synthesis in the mucosa. This randomized clinical trial was undertaken to evaluate its effect in preventing acute radiation enteritis (ARE).