Fabrication and modification of composite silica nano test tubes for targeted drug delivery


Buyukserin F., Altuntas S., Aslim B.

RSC ADVANCES, vol.4, no.45, pp.23535-23539, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 45
  • Publication Date: 2014
  • Doi Number: 10.1039/c4ra00871e
  • Journal Name: RSC ADVANCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.23535-23539
  • Gazi University Affiliated: Yes

Abstract

This work describes the use of template synthesis to fabricate multifunctional composite silica nano test tubes for targeted drug delivery. The tubular nanostructures were formed within nanoporous anodized alumina templates and their inner voids were filled with a drug-bearing gel matrix while the test tubes were embedded within the template. Upon template removal, the composite nanocarriers were bio-functionalized with a targeting moiety towards breast cancer cells. The results show that targeting is critical in inducing cell death and the targeted nanocarriers are extensively more cytotoxic towards cancer cells compared with healthy controls.