Development and characterization of rapid dissolving ornidazole loaded PVP electrospun fibers

TORT S., Yildiz A., TUĞCU DEMİRÖZ F. N., AKCA G., Kuzukiran O., ACARTÜRK F.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, sa.7, ss.864-873, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/10837450.2019.1615088
  • Dergi Adı: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.864-873
  • Anahtar Kelimeler: Electrospinning, electrospun fibers, rapid dissolving, ornidazole, gingivitis, DRUG-DELIVERY-SYSTEMS, MUCOADHESIVE POLYMERS, NANOFIBER, MEMBRANES, CHITOSAN, RELEASE, FILMS
  • Gazi Üniversitesi Adresli: Evet

Özet

Gingivitis is a common and mild form of periodontal disease and can be described as a limited inflammation of the gingiva. This study aims to develop and characterize rapid releasing mucoadhesive fibers containing ornidazole with electrospinning process for the treatment of gingivitis. Polyvinylpyrrolidone (PVP) was chosen as a polymer and used at different concentrations of 10%, 12.5%, and 15%. Scanning electron microscopy images showed that fiber diameters increased with increasing polymer concentrations. Tensile strength and elongation at break values of fibers increased with increasing PVP amount, whereas the loading of ornidazole into the fibers decreased these parameters. The contact angle values of all fibers were found to be 0 degrees due to the hydrophilic nature of PVP. Ornidazole was released within 5min and diffused from all of the fibers faster than that of gel and solution formulations. Electrospun ornidazole fibers were found efficient against Porphyromonas gingivalis in antimicrobial activity studies. The results demonstrated that ornidazole loaded fibers could be a potential drug delivery system for the treatment of gingivitis.