In Vitro Cytotoxic Activities of Platinum(II) Complex with 1-Methyl-2-(3 '-hydroxypropyl)benzimidazole and 2-(3 '-Hydroxypropyl)benzimidazolium Hexa- and Tetrachloroplatinate Salts

EREN G., Yilmaz S., Gumus F.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.1, ss.65-69, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1570180814666171012163325
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.65-69
  • Anahtar Kelimeler: Platinum complex, benzimidazole, cytotoxic activity, in vitro, DNA, RNA, SUBSTITUTED BENZIMIDAZOLE LIGANDS, DNA INTERACTIONS, BINDING, DRUGS, 2-HYDROXYMETHYLBENZIMIDAZOLE, THERAPEUTICS, CISPLATIN, CHEMISTRY, AGENTS, MCF-7
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Platinum complexes as antitumor agents have received considerable attention due to the clinically approved and have been marketed worldwide such as cisplatin, carboplatin, oxaliplatin or marketed locally such as nedaplatin, lobaplatin and heptaplatin for treatment of various tumor diseases. However, those drugs still had their own defects and they exhibited side effects including nephrotoxicity, ototoxicity, neurotoxicity and bone marrow suppression. Therefore there is still continuing interest in the development of new platinum drugs avoiding their inherent resistance and toxicity.