Ovarian cancer is the leading cause of death among gynecological cancers. Spleen is an infrequent site of the tumor metastases as isolated parenchymal splenic metastasis occurs rarely in ovarian cancer. Metastatic splenic involvement usually indicates an extensive tumor dissemination through retroperitoneal lymph nodes or the peritoneum in ovarian cancer. In this case, 3 years after the initial diagnosis, although conventional imaging methods reported the splenic lesion as suspicious for malignancy, positron emission tomography/computarized tomography (PET/CT) reported it as malignant despite a normal CA 125 level. In this paper, we reviewed the literature for isolated splenic metastases, and stressed the role of PET/CT in recurrent ovarian cancer.