New steroidal alkaloids from the roots of Buxus sempervirens


AttaurRahman A., Choudhary M., Naz S., Ata A., Sener B., Turkoz S.

JOURNAL OF NATURAL PRODUCTS, cilt.60, ss.770-774, 1997 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 60 Konu: 8
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1021/np970028x
  • Dergi Adı: JOURNAL OF NATURAL PRODUCTS
  • Sayfa Sayıları: ss.770-774

Özet

Phytochemical studies on the ethanolic extract of the roots of Buxus sempervirens L. of Turkish origin have resulted in the isolation of four new steroidal alkaloids, (+)-16 alpha-hydroxy-N-a-benzoylbuxadine [(20S)-16 alpha-hydroxy-3 beta-(benzoylamino)-20- (dimethylamino)-9,10-seco-buxa-9(11),1(10)-diene] (1), (+)-semperviraminone [3 beta-(dimethylamino)-20-oxo-9,10-seco-buxa-9(11),1-(10),16(17)-triene] (2), (+)-N-a-demethylsemperviraminone [3 beta-(methylamino)-20-oxo-9,10-seco-buxa-9(11),1(10),16(17)-triene] (3), and (+)-buxaminol-C [(20S)-16 alpha-hydroxy-3 beta-(methylamino)-20-(dimethylamino)-9,10-seco-buxa-9(11) ,10(19)-diene] (4). Four known steroidal alkamines, (-)-(E)-cyclobuxaphylamine [(20E)-16-oxo-3 beta-(methylamino)-9 beta,10 beta-cyclobuxa-7(8),17(20)-diene] (5), (-)-(Z)-cyclobuxaphylamine [(20Z)-16-oxo-3 beta-(methylamino)-9 beta,10 beta-cyclobuxa-7(8),17(20)-diene] (6), (+)-cyclomicrobuxeine [3 beta-(dimethylamino)-20-oxo-9 beta,10 beta-cyclobuxa-4(30),16(17)- diene] (7), and (+)-papilamine [(20S)-3 beta,20-bis(methylamino)-9,10-seco-buxa-9(11),10(19)-diene] (8), were also isolated for the first time from this species. Their structures were elucidated on the basis of extensive spectroscopic studies.