Atıf İçin Kopyala
Durak Z. E.
NEUROLOGY, cilt.88, sa.16 Ek, ss.5-7, 2017 (SCI-Expanded)
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Yayın Türü:
Makale / Kısa Makale
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Cilt numarası:
88
Sayı:
16 Ek
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Basım Tarihi:
2017
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Doi Numarası:
10.1212/wnl.88.16_supplement.p1.009
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Dergi Adı:
NEUROLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.5-7
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Gazi Üniversitesi Adresli:
Evet
Özet
Abstract
Objective:
We aimed to investigate oxidative and anti-oxidative status in Parkinson’s Disease (PD) patients and their possible association between age, disease duration, Hoehn and Yahr stages (H&Y) and the Unified Parkinson’s Disease Rating Scale (UPDRS) scores of the patients and these markers.
Background:
Combination of genetic and environmental factors are thought to contribute to the development of PD, but the underlying exact mechanism still remains unclear. Oxidative stress has been hypothesized to play a major role in the development of PD in various studies.
Design/Methods:
We evaluated oxidant/antioxidant status by measuring serum paraoxonase-1 (PON1) and catalase (CAT) activities and lipid, ferritin and uric acid levels. The study included 32 patients with PD and 32 age-and sex-matched healthy subjects as controls.
Results:
Serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and ferrritin levels were significantly reduced and PON1 activities were significantly increased in patients with PD (p<0,05). Serum high-density lipoprotein cholesterol (HDL-C), uric acid and CAT levels in PD patients were not significantly different from the controls (p>0,05). TC and LDL-C were negatively correlated with H&Y stage ( r= −0,385 p<0,05 and r= −0,349, p<0,05 respectively).
Conclusions:
Our results suggest that oxidative stress might contribute to the neurodegeneration in PD. More studies may be needed to explore the role of oxidant and antioxidant status in patients with PD and reach to a definite conclusion.