The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms Alzheimer Hastalığı Açısından Demir, Bakır, Çinko ve Magnezyum Dishomeostazisinin Önemi ve Olası Mekanizmalar

TEKİN E., Küçük A., ARSLAN M.

Gazi Medical Journal, cilt.35, sa.1, ss.100-105, 2024 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.4274/gmj.galenos.2023.3865
  • Dergi Adı: Gazi Medical Journal
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.100-105
  • Anahtar Kelimeler: Alzheimer’s disease, copper, dyshomeostasis, iron, magnesium, zinc
  • Gazi Üniversitesi Adresli: Evet

Özet

Alzheimer’s disease (AD) affects many people around the world, and its incidence is increasing. In addition to the amyloid cascade hypothesis, different mechanisms are discussed for AD, which has no definitive treatment. Studies have shown that the levels of metal cations such as iron, copper, zinc, and magnesium vary and their metabolism are impaired in patients with AD. Metal cation dyshomeostasis is believed to be one of the mechanisms that contribute to the development of AD. In this review, we aimed to evaluate various metal cations in terms of AD.