TURKISH JOURNAL OF CHEMISTRY, vol.36, no.5, pp.734-748, 2012 (SCI-Expanded)
Article / Article
TURKISH JOURNAL OF CHEMISTRY
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Hybrid, antipyrine, pyridazinone, writhing, carrageenan, SELECTIVE CYCLOOXYGENASE-2 INHIBITORS, 3(2H)-PYRIDAZINONE DERIVATIVES, ANTINOCICEPTIVE ACTIVITY, AMIDE DERIVATIVES, RATS, CARRAGEENAN, ACID, DRUG, INDOMETHACIN, ULCER
Gazi University Affiliated:
Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone-induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated that compounds 6a, 6c, and 6d were equally or more potent analgesic and anti-inflammatory agents than aspirin and indomethacin, respectively. Side effects of the compounds were examined on gastric mucosa. Most of the compounds were found to be non-ulcerogenic under test conditions.