Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities

BAYTAŞ S., Inceler N., Mavaneh K. F., ULUDAĞ M. O., Abacioglu N., Gokce M.

TURKISH JOURNAL OF CHEMISTRY, cilt.36, sa.5, ss.734-748, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3906/kim-1111-29
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.734-748
  • Anahtar Kelimeler: Hybrid, antipyrine, pyridazinone, writhing, carrageenan, SELECTIVE CYCLOOXYGENASE-2 INHIBITORS, 3(2H)-PYRIDAZINONE DERIVATIVES, ANTINOCICEPTIVE ACTIVITY, AMIDE DERIVATIVES, RATS, CARRAGEENAN, ACID, DRUG, INDOMETHACIN, ULCER
  • Gazi Üniversitesi Adresli: Evet

Özet

Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone-induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated that compounds 6a, 6c, and 6d were equally or more potent analgesic and anti-inflammatory agents than aspirin and indomethacin, respectively. Side effects of the compounds were examined on gastric mucosa. Most of the compounds were found to be non-ulcerogenic under test conditions.