Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities


BAYTAŞ S., Inceler N., Mavaneh K. F. , ULUDAĞ M. O. , Abacioglu N., Gokce M.

TURKISH JOURNAL OF CHEMISTRY, vol.36, no.5, pp.734-748, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.3906/kim-1111-29
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.734-748
  • Keywords: Hybrid, antipyrine, pyridazinone, writhing, carrageenan, SELECTIVE CYCLOOXYGENASE-2 INHIBITORS, 3(2H)-PYRIDAZINONE DERIVATIVES, ANTINOCICEPTIVE ACTIVITY, AMIDE DERIVATIVES, RATS, CARRAGEENAN, ACID, DRUG, INDOMETHACIN, ULCER
  • Gazi University Affiliated: Yes

Abstract

Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone-induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated that compounds 6a, 6c, and 6d were equally or more potent analgesic and anti-inflammatory agents than aspirin and indomethacin, respectively. Side effects of the compounds were examined on gastric mucosa. Most of the compounds were found to be non-ulcerogenic under test conditions.