A new sesquiterpene, prosoterpene, from Prosopis africana (Guill. & Perr.) Taub

Ali R., Salawu K. M., Aamer M., Jahan H., Tufail P., Irshad R., ...Daha Fazla

NATURAL PRODUCT RESEARCH, cilt.37, sa.19, ss.3220-3227, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 19
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/14786419.2022.2062755
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.3220-3227
  • Anahtar Kelimeler: Prosopis africana, sesquiterpene, prosoterpene, quercetin-3-O-alpha-L-rhamnoside, anti-glycation, PIPERIDINE ALKALOIDS, ANTIOXIDANT, EXTRACTS, PLANTS
  • Gazi Üniversitesi Adresli: Evet

Özet

A new sesquiterpene (Prosoterpene, 1) and eleven reported compounds (2-12) of several classes, such as flavonoids, alkaloids, phenolic acids, and long-chain alcohols, were isolated from the BuOH extract of Prosopis africana (Guill. & Perr.) Taub. Compounds 2-10 were reported for the first time from this plant. Isomers 11 and 12 were separated for the first time. Extensive spectroscopic techniques and literature comparisons were used to characterise their structures. Furthermore, compounds 3, 5-8, and 10-12 were performed for anti-glycation and cytotoxicity activities. Compound 3 (quercetin-3-O-alpha-L-rhamnoside) exhibited moderate anti-glycation activity. All tested compounds were noncytotoxic against MCF-7 (breast cancer), NCI-H460 (lung cancer), Hela (cervical cancer), and BJ (normal human fibroblast) cell lines.