Biochemical alterations in neonatal hypoxic ischaemic brain damage

Gucuyener, K; Gur, T; Oz, E; Turkyilmaz, CANAN; Ozturk, G; Erbas, D; Atalay, Y; Hasanoglu, A

doi:10.1016/s0952-3278(97)90562-7

Biochemical alterations in neonatal hypoxic ischaemic brain damage

Gucuyener K., Gur T., Oz E., Turkyilmaz C., Ozturk G., Erbas D., ...Daha Fazla

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.57, sa.6, ss.567-570, 1997 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 57 Sayı: 6
Basım Tarihi: 1997
Doi Numarası: 10.1016/s0952-3278(97)90562-7
Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.567-570
Gazi Üniversitesi Adresli: Evet

Özet

Asphyxiated (n = 39) and control (n = 23) were elected for the study. Free radical-mediated lipid peroxidation, prostaglandin E-2 and vitamin E levels were studied and the degree of hypoxic ischaemic encephalopathy was determined in each case. In the hypoxic group the concentration of prostaglandin E-2 activity (P < 0.05) and malondialdehyde levels (P < 0.01) were significantly higher when compared to that of controls. The high vitamin E concentrations in the asphyxiated infants supports the role of oxygen free radicals in hypoxic ischaemic encephalopathy of newborns.