New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities

Creative Commons License

Atta-ur-Rahman A., Akhtar M., Choudhary M., Tsuda Y., Sener B., Khalid A., ...More

CHEMICAL & PHARMACEUTICAL BULLETIN, vol.50, no.8, pp.1013-1016, 2002 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 8
  • Publication Date: 2002
  • Doi Number: 10.1248/cpb.50.1013
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1013-1016
  • Keywords: Fritillaria imperialis, impericine, forticine, cevanine-type, acetylcholinesterase, butyrylcholinesterase, ELUCIDATION


Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta,8-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.