New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities

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Atta-ur-Rahman A., Akhtar M., Choudhary M., Tsuda Y., Sener B., Khalid A., ...Daha Fazla

CHEMICAL & PHARMACEUTICAL BULLETIN, cilt.50, sa.8, ss.1013-1016, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 8
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1248/cpb.50.1013
  • Dergi Adı: CHEMICAL & PHARMACEUTICAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1013-1016
  • Anahtar Kelimeler: Fritillaria imperialis, impericine, forticine, cevanine-type, acetylcholinesterase, butyrylcholinesterase, ELUCIDATION
  • Gazi Üniversitesi Adresli: Hayır

Özet

Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta,8-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.