Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue

Peker E. G. G. , COŞKUN CEVHER Ş., EBEGİL M., Acarturk F.

MEDICINAL CHEMISTRY RESEARCH, vol.19, no.6, pp.533-540, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1007/s00044-009-9210-z
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.533-540
  • Keywords: Epidermal growth factor, Oral wound healing, Myeloperoxidase, Antioxidant capacity, ASCORBIC-ACID, HYDROGEN-PEROXIDE, GASTRIC-MUCOSA, FACTOR-ALPHA, GLUTATHIONE, FORMULATION, STRESS, OXYGEN, RATS, NEUTROPHILS
  • Gazi University Affiliated: Yes


Growth factors and cytokines are key regulators of the wound-healing process. Epidermal growth factor (EGF) plays a vital role during the process of wound healing. There are limited numbers of studies related to EGF implantation effects on oxidative stress in oral wound healing. The objective of this study was to investigate the effect of EGF on myeloperoxidase (MPO) activity and nonenzymatic antioxidant levels of oral wound tissue on different days. In this study, New Zealand male albino rabbits were used. After submucosal incisions, the rabbits were divided into two equal groups: untreated wounds, and EGF-implanted wounds. The levels of glutathione (GSH), ascorbic acid (AA), and MPO activity were measured spectrophotometrically. As a result, MPO activity of oral wound tissue strips was increased by exogenous EGF treatment compared with controls. In addition, GSH and AA levels of oral wound tissue strips were not changed during oral wound-healing phases for both controls and experimental groups.