Akademik Veri Yönetim Sistemi
6. Pediatrik Rehabilitasyon Kongresi, Antalya, Türkiye, 5 - 07 Haziran 2021, cilt.8, sa.21488819, ss.38-39
RELATIONSHIP BETWEEN MUSCLE OXYGENATION AND EXERCISE CAPACITY, RESPIRATORY AND PERIPHERAL
MUSCLE STRENGTH IN PATIENTS WITH CYSTIC FIBROSIS
Purpose: Respiratory and peripheral muscle weakness, exercise intolerance, mitochondial involvement and slow
phosphocreatine metabolism are common in patients with cystic fibrosis (CF), but studies are limited investigating oxygen
metabolism at the cellular level. The relationship between muscle oxygenation and functional exercise capacity, respiration
and peripheral muscle strength in patients with CF is unknown, therefore this study was conducted.
Methods: Eighteen children with CF (11E, 7K, 10.55±3.12 years, Shwachman-Kulczycki score=81.66±12 point,
%FEV1=79±27.15) were included.Quadriceps femoris muscle oxygenation (%SmO2rest, %SmO2min,%SmO2recovery) and total
hemoglobin level (Thbrest, Thbmin, Thbrecovery) were measured at rest and during the 6-minute walk test (6-MWT) and after the
test ("Moxy" monitor).Exercise capacity (6-MWT), respiratory muscle strength [(MIP-MEP) (mouth pressure measuring
device)], quadriceps femoris muscle strength (dynamometer) were evaluated.
Results: The six-minute walking test distance (%) was statistically significantly (r=-0.497 p=0.042) and negatively correlated
with %SmO2min (p<0.05). MIP was statistically significantly (r=-0.652 p=0.005) and negatively correlated with Thbmin
(p<0.05). No statistically significant relationships were present between the MEP and %SmO2rest, Thbrest, %SmO2min, Thbmin,
%SmO2recovery, Thbrecovery (p>0.05). Quadriceps femoris muscle strength was statistically significant (right:r=0.587 p=0.013,
left:r=0.557 p=0.02) and positively correlated with %SmO2recovery (p<0.05).
Conclusion: As the six-minute walking test distance increases, muscle oxygen saturation during exercise decreases in
patients with cystic fibrosis. As the inspiratory muscle strength increases during exercise, patients’quadriceps femoris total
hemoglobin level decreases. As the quadriceps femoris muscle strength decreases, the patient's muscle oxygen saturation
in exercise recovery phase decreases. These results show abnormalities in oxygen use in metabolic level. The effects of
exercise on muscle oxygenation and muscle hemoglobin levels should be investigated.
Keywords: Cystic Fibrosis, Muscle Oxygenation, Respiratory Muscles, Six Minute Walk Test