Relationship Between Muscle Oxygenation and Exercise Capacity, Respiratory and Peripheral Muscle Strength in Patients with Cystic Fibrosis


Yoleri B., Boşnak Güçlü M., Şişmanlar Eyüboğlu T., Aslan A. T.

6. Pediatrik Rehabilitasyon Kongresi, Antalya, Turkey, 5 - 07 June 2021, vol.8, no.21488819, pp.38-39

  • Publication Type: Conference Paper / Summary Text
  • Volume: 8
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.38-39

Abstract

RELATIONSHIP BETWEEN MUSCLE OXYGENATION AND EXERCISE CAPACITY, RESPIRATORY AND PERIPHERAL MUSCLE STRENGTH IN PATIENTS WITH CYSTIC FIBROSIS Purpose: Respiratory and peripheral muscle weakness, exercise intolerance, mitochondial involvement and slow phosphocreatine metabolism are common in patients with cystic fibrosis (CF), but studies are limited investigating oxygen metabolism at the cellular level. The relationship between muscle oxygenation and functional exercise capacity, respiration and peripheral muscle strength in patients with CF is unknown, therefore this study was conducted. Methods: Eighteen children with CF (11E, 7K, 10.55±3.12 years, Shwachman-Kulczycki score=81.66±12 point, %FEV1=79±27.15) were included.Quadriceps femoris muscle oxygenation (%SmO2rest, %SmO2min,%SmO2recovery) and total hemoglobin level (Thbrest, Thbmin, Thbrecovery) were measured at rest and during the 6-minute walk test (6-MWT) and after the test ("Moxy" monitor).Exercise capacity (6-MWT), respiratory muscle strength [(MIP-MEP) (mouth pressure measuring device)], quadriceps femoris muscle strength (dynamometer) were evaluated. Results: The six-minute walking test distance (%) was statistically significantly (r=-0.497 p=0.042) and negatively correlated with %SmO2min (p<0.05). MIP was statistically significantly (r=-0.652 p=0.005) and negatively correlated with Thbmin (p<0.05). No statistically significant relationships were present between the MEP and %SmO2rest, Thbrest, %SmO2min, Thbmin, %SmO2recovery, Thbrecovery (p>0.05). Quadriceps femoris muscle strength was statistically significant (right:r=0.587 p=0.013, left:r=0.557 p=0.02) and positively correlated with %SmO2recovery (p<0.05). Conclusion: As the six-minute walking test distance increases, muscle oxygen saturation during exercise decreases in patients with cystic fibrosis. As the inspiratory muscle strength increases during exercise, patients’quadriceps femoris total hemoglobin level decreases. As the quadriceps femoris muscle strength decreases, the patient's muscle oxygen saturation in exercise recovery phase decreases. These results show abnormalities in oxygen use in metabolic level. The effects of exercise on muscle oxygenation and muscle hemoglobin levels should be investigated. Keywords: Cystic Fibrosis, Muscle Oxygenation, Respiratory Muscles, Six Minute Walk Test