Graves' orbitopathy as a rare disease in Europe: a European Group on Graves' Orbitopathy (EUGOGO) position statement

---

Atıf İçin Kopyala

Perros P., Hegedus L., Bartalena L., Marcocci C., Kahaly G. J., Baldeschi L., ...Daha Fazla

ORPHANET JOURNAL OF RARE DISEASES, cilt.12, 2017 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 12
• Basım Tarihi: 2017
• Doi Numarası: 10.1186/s13023-017-0625-1
• Dergi Adı: ORPHANET JOURNAL OF RARE DISEASES
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Anahtar Kelimeler: Graves' orbitopathy, Ophthalmopathy, Prevalence, Incidence, Epidemiology, Rare disease, EUGOGO, FOLLOW-UP, NATURAL-HISTORY, THYROID EPIDEMIOLOGY, PREVALENCE, OPHTHALMOPATHY, HYPERTHYROIDISM, FEATURES
• Gazi Üniversitesi Adresli: Evet

Özet

Background: Graves' orbitopathy (GO) is an autoimmune condition, which is associated with poor clinical outcomes including impaired quality of life and socio-economic status. Current evidence suggests that the incidence of GO in Europe may be declining, however data on the prevalence of this disease are sparse. Several clinical variants of GO exist, including euthyroid GO, recently listed as a rare disease in Europe (ORPHA466682). The objective was to estimate the prevalence of GO and its clinical variants in Europe, based on available literature, and to consider whether they may potentially qualify as rare. Recent published data on the incidence of GO and Graves' hyperthyroidism in Europe were used to estimate the prevalence of GO. The position statement was developed by a series of reviews of drafts and electronic discussions by members of the European Group on Graves' Orbitopathy. The prevalence of GO in Europe is about 10/10,000 persons. The prevalence of other clinical variants is also low: hypothyroid GO 0.02-1.10/10,000; GO associated with dermopathy 0.15/10,000; GO associated with acropachy 0.03/10,000; asymmetrical GO 1.00-5.00/10,000; unilateral GO 0.50-1.50/10,000.