Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives


Gokce M., DOĞRUER D. S. , Sahin M.

FARMACO, vol.56, no.3, pp.233-237, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1016/s0014-827x(01)01037-0
  • Title of Journal : FARMACO
  • Page Numbers: pp.233-237

Abstract

A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test. (C) 2001 Elsevier Science S.A. All rights reserved.