Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives

Gokce M., DOĞRUER D. S. , Sahin M.

FARMACO, vol.56, no.3, pp.233-237, 2001 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1016/s0014-827x(01)01037-0
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.233-237
  • Keywords: 6-substituted-3-pyridazinone derivatives, antinociceptive activity, Koster test, AGENTS, CARDIOTONICS


A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test. (C) 2001 Elsevier Science S.A. All rights reserved.