Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives

Gokce M., DOĞRUER D. S. , Sahin M.

FARMACO, cilt.56, sa.3, ss.233-237, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Konu: 3
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0014-827x(01)01037-0
  • Dergi Adı: FARMACO
  • Sayfa Sayıları: ss.233-237


A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test. (C) 2001 Elsevier Science S.A. All rights reserved.