The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta


HAN S. , BAL N. B. , SADİ G., USANMAZ S. E. , ULUDAĞ M. O. , DEMİREL YILMAZ E.

LIFE SCIENCES, vol.213, pp.287-293, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 213
  • Publication Date: 2018
  • Doi Number: 10.1016/j.lfs.2018.10.042
  • Title of Journal : LIFE SCIENCES
  • Page Numbers: pp.287-293
  • Keywords: Hypertension, Liver X receptors, GW3965, Inflammation, Aorta, ENDOTHELIAL DYSFUNCTION, QUERCETIN TREATMENT, OXIDATIVE STRESS, RECEPTOR, INVOLVEMENT, EXPRESSION, CELLS, CONTRACTION, INHIBITION, RESISTANCE

Abstract

Aims: Liver X receptors (LXRs) play an important role in the regulation of cholesterol, fatty acid and glucose metabolisms together with inflammatory processes. In the present study, the effects of LXR agonist GW3965 on vascular reactivity and expression of functional proteins in DOCA-Salt induced hypertension were examined.