The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta


HAN S., BAL N. B. , SADİ G., USANMAZ S. E. , ULUDAĞ M. O. , DEMİREL YILMAZ E.

LIFE SCIENCES, vol.213, pp.287-293, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 213
  • Publication Date: 2018
  • Doi Number: 10.1016/j.lfs.2018.10.042
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.287-293
  • Keywords: Hypertension, Liver X receptors, GW3965, Inflammation, Aorta, ENDOTHELIAL DYSFUNCTION, QUERCETIN TREATMENT, OXIDATIVE STRESS, RECEPTOR, INVOLVEMENT, EXPRESSION, CELLS, CONTRACTION, INHIBITION, RESISTANCE
  • Gazi University Affiliated: Yes

Abstract

Aims: Liver X receptors (LXRs) play an important role in the regulation of cholesterol, fatty acid and glucose metabolisms together with inflammatory processes. In the present study, the effects of LXR agonist GW3965 on vascular reactivity and expression of functional proteins in DOCA-Salt induced hypertension were examined.