STROKE, vol.31, no.8, pp.1974-1980, 2000 (Journal Indexed in SCI)
Article / Article
Title of Journal :
cerebral ischemia, focal, matrix metalloproteinases, nitrates, nitric oxide, reperfusion injury, L-ARGININE, SYNTHASE INHIBITOR, ARTERY OCCLUSION, 7-NITRO INDAZOLE, INFARCT VOLUME, NOS INHIBITOR, RAT-BRAIN, L-NAME, SUPEROXIDE, STROKE
Background and Purpose-Reperfusion injury is one of the factors that unfavorably affects stroke outcome and shortens the window of opportunity for thrombolysis. Surges of nitric oxide (NO) and superoxide generation on reperfusion have been demonstrated. Concomitant generation of these radicals can lead to formation of the strong oxidant peroxynitrite during reperfusion.