Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia

Gursoy-Ozdemir Y., Bolay H. B., Saribas O., Dalkara T.

STROKE, cilt.31, sa.8, ss.1974-1980, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 8
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1161/01.str.31.8.1974
  • Dergi Adı: STROKE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1974-1980
  • Anahtar Kelimeler: cerebral ischemia, focal, matrix metalloproteinases, nitrates, nitric oxide, reperfusion injury, L-ARGININE, SYNTHASE INHIBITOR, ARTERY OCCLUSION, 7-NITRO INDAZOLE, INFARCT VOLUME, NOS INHIBITOR, RAT-BRAIN, L-NAME, SUPEROXIDE, STROKE
  • Gazi Üniversitesi Adresli: Hayır

Özet

Background and Purpose-Reperfusion injury is one of the factors that unfavorably affects stroke outcome and shortens the window of opportunity for thrombolysis. Surges of nitric oxide (NO) and superoxide generation on reperfusion have been demonstrated. Concomitant generation of these radicals can lead to formation of the strong oxidant peroxynitrite during reperfusion.