Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia


Gursoy-Ozdemir Y., Bolay H. B. , Saribas O., Dalkara T.

STROKE, vol.31, no.8, pp.1974-1980, 2000 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 8
  • Publication Date: 2000
  • Doi Number: 10.1161/01.str.31.8.1974
  • Title of Journal : STROKE
  • Page Numbers: pp.1974-1980
  • Keywords: cerebral ischemia, focal, matrix metalloproteinases, nitrates, nitric oxide, reperfusion injury, L-ARGININE, SYNTHASE INHIBITOR, ARTERY OCCLUSION, 7-NITRO INDAZOLE, INFARCT VOLUME, NOS INHIBITOR, RAT-BRAIN, L-NAME, SUPEROXIDE, STROKE

Abstract

Background and Purpose-Reperfusion injury is one of the factors that unfavorably affects stroke outcome and shortens the window of opportunity for thrombolysis. Surges of nitric oxide (NO) and superoxide generation on reperfusion have been demonstrated. Concomitant generation of these radicals can lead to formation of the strong oxidant peroxynitrite during reperfusion.