SYMPHYTOXIDE-A, A TRITERPENOID SAPONIN FROM THE ROOTS OF SYMPHYTUM-OFFICINALE

AHMAD V., NOORWALA M., MOHAMMAD F., SENER B., GILANI A., AFTAB K.

PHYTOCHEMISTRY, cilt.32, ss.1003-1006, 1993 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 4
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/0031-9422(93)85244-l
  • Dergi Adı: PHYTOCHEMISTRY
  • Sayfa Sayıları: ss.1003-1006

Özet

A new triterpenoidal saponin of hederagenin named symphytoxide A has been isolated from the ethanolic extract of the roots of Symphytum officinale and characterized on the basis of chemical investigations and spectroscopic studies as 3-O-[beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 4)-alpha-L-arabinopyranosyl] hederagenin. The structure of this new saponin was established on the basis of ID and 2D NMR experiments including heteroCOSY, COSY-45-degrees as well as HMBC measurements and other spectroscopic techniques. The saponin exhibited hypotensive activity in anaesthetized rats.