PHYTOCHEMISTRY, cilt.32, ss.1003-1006, 1993 (SCI İndekslerine Giren Dergi)
A new triterpenoidal saponin of hederagenin named symphytoxide A has been isolated from the ethanolic extract of the roots of Symphytum officinale and characterized on the basis of chemical investigations and spectroscopic studies as 3-O-[beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 4)-alpha-L-arabinopyranosyl] hederagenin. The structure of this new saponin was established on the basis of ID and 2D NMR experiments including heteroCOSY, COSY-45-degrees as well as HMBC measurements and other spectroscopic techniques. The saponin exhibited hypotensive activity in anaesthetized rats.