The Schrodinger equation in three-dimensional space with constant positive curvature is studied for the Mie potential. Using analytic polynomial solutions, we have obtained whole spectrum of the corresponding system. With the aid of factorization method, ladder operators are obtained within the variable and function transformations. Using ladder operators, we have given the generators of so(2, 1) algebra and the Casimir operator which are related to the Mie Oscillator on the positive curvature. (C) 2012 Elsevier B.V. All rights reserved.