Dexmedetomidine protects from post-myocardial ischaemia reperfusion lung damage in diabetic rats


Creative Commons License

KİP G. , ÇELİK A. , Bilge M., ALKAN M. , KİRAZ H. A. , ÖZER A. , ...More

LIBYAN JOURNAL OF MEDICINE, vol.10, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2015
  • Doi Number: 10.3402/ljm.v10.27828
  • Title of Journal : LIBYAN JOURNAL OF MEDICINE

Abstract

Objective: Diabetic complications and lipid peroxidation are known to have a close association. Lipid peroxidation commonly occurs at sites exposed to ischaemia, but distant organs and tissues also get damaged during ischaemia/reperfusion (I/R). Some of these targets are vital organs, such as the lung, liver, and kidney; the lung is the most frequently affected. The aim of our study was to investigate the effects of dexmedetomidine on I/R damage in lung tissue and on the oxidant/anti-oxidant system in diabetic rats.