Dexmedetomidine protects from post-myocardial ischaemia reperfusion lung damage in diabetic rats


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KİP G., ÇELİK A., Bilge M., ALKAN M., KİRAZ H. A., ÖZER A., ...More

LIBYAN JOURNAL OF MEDICINE, vol.10, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2015
  • Doi Number: 10.3402/ljm.v10.27828
  • Journal Name: LIBYAN JOURNAL OF MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Diabetes Mellitus, dexmedetomidine, ischaemia reperfusion, lung, ISCHEMIA/REPERFUSION INJURY, FREE-RADICALS, LEVOSIMENDAN, EXPRESSION, LIVER, MICE
  • Gazi University Affiliated: Yes

Abstract

Objective: Diabetic complications and lipid peroxidation are known to have a close association. Lipid peroxidation commonly occurs at sites exposed to ischaemia, but distant organs and tissues also get damaged during ischaemia/reperfusion (I/R). Some of these targets are vital organs, such as the lung, liver, and kidney; the lung is the most frequently affected. The aim of our study was to investigate the effects of dexmedetomidine on I/R damage in lung tissue and on the oxidant/anti-oxidant system in diabetic rats.