Dexmedetomidine protects from post-myocardial ischaemia reperfusion lung damage in diabetic rats
LIBYAN JOURNAL OF MEDICINE, cilt.10, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10
- Basım Tarihi: 2015
- Doi Numarası: 10.3402/ljm.v10.27828
- Dergi Adı: LIBYAN JOURNAL OF MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Diabetes Mellitus, dexmedetomidine, ischaemia reperfusion, lung, ISCHEMIA/REPERFUSION INJURY, FREE-RADICALS, LEVOSIMENDAN, EXPRESSION, LIVER, MICE
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Objective: Diabetic complications and lipid peroxidation are known to have a close association. Lipid peroxidation commonly occurs at sites exposed to ischaemia, but distant organs and tissues also get damaged during ischaemia/reperfusion (I/R). Some of these targets are vital organs, such as the lung, liver, and kidney; the lung is the most frequently affected. The aim of our study was to investigate the effects of dexmedetomidine on I/R damage in lung tissue and on the oxidant/anti-oxidant system in diabetic rats.