Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.


ŞENOL DENİZ F. S. , Slusarczyk S., Matkowski A., Perez-Garrido A., Giron-Rodriguez F., Ceron-Carrasco J. P. , ...More

PHYTOCHEMISTRY, vol.133, pp.33-44, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 133
  • Publication Date: 2017
  • Doi Number: 10.1016/j.phytochem.2016.10.012
  • Journal Name: PHYTOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.33-44
  • Keywords: Perovskia atriplicifolia (Lamiaceae), Salvia glutinosa (Lamiaceae), Tanshinones, Diterpenes, Cholinesterase inhibition, Butyrylcholinesterase, QSAR, Molecular modeling, ACETYLCHOLINESTERASE INHIBITORS, TANSHINONES, MILTIORRHIZA, MODELS, CHARGES, MOUSE
  • Gazi University Affiliated: Yes

Abstract

Cholinesterase inhibition is one of the most treatment strategies against Alzheimer's disease (AD) where metal accumulation is also strongly associated with pathology of the disease. In the current study, we assessed inhibitory effect against acetyl- (AChE) and butyrylcholinesterase (BChE) and metal-chelating capacity of twelve diterpenes: arucadiol, miltirone, tanshinone Ha, 1-oxomiltirone, cryptotanshinone, 1,2-didehydromiltirone, 1,2-didehydrotanshinone IIa, 1 beta-hydroxycryptotanshinone, 15,16-dihydrotanshinone, tanshinone I, isotanshinone II, 1(S)-hydroxytanshinone IIa, and rosmarinic acid, isolated from Perovskia atriplicifolia and Salvia glutinosa. The compounds were tested at 10 mu g/mL using ELISA microtiter assays against AChE and BChE. QSAR and molecular docking studies have been also performed on the active compounds.