Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.

ŞENOL DENİZ F. S., Slusarczyk S., Matkowski A., Perez-Garrido A., Giron-Rodriguez F., Ceron-Carrasco J. P., ...Daha Fazla

PHYTOCHEMISTRY, cilt.133, ss.33-44, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 133
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.phytochem.2016.10.012
  • Dergi Adı: PHYTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.33-44
  • Anahtar Kelimeler: Perovskia atriplicifolia (Lamiaceae), Salvia glutinosa (Lamiaceae), Tanshinones, Diterpenes, Cholinesterase inhibition, Butyrylcholinesterase, QSAR, Molecular modeling, ACETYLCHOLINESTERASE INHIBITORS, TANSHINONES, MILTIORRHIZA, MODELS, CHARGES, MOUSE
  • Gazi Üniversitesi Adresli: Evet

Özet

Cholinesterase inhibition is one of the most treatment strategies against Alzheimer's disease (AD) where metal accumulation is also strongly associated with pathology of the disease. In the current study, we assessed inhibitory effect against acetyl- (AChE) and butyrylcholinesterase (BChE) and metal-chelating capacity of twelve diterpenes: arucadiol, miltirone, tanshinone Ha, 1-oxomiltirone, cryptotanshinone, 1,2-didehydromiltirone, 1,2-didehydrotanshinone IIa, 1 beta-hydroxycryptotanshinone, 15,16-dihydrotanshinone, tanshinone I, isotanshinone II, 1(S)-hydroxytanshinone IIa, and rosmarinic acid, isolated from Perovskia atriplicifolia and Salvia glutinosa. The compounds were tested at 10 mu g/mL using ELISA microtiter assays against AChE and BChE. QSAR and molecular docking studies have been also performed on the active compounds.